In part II, “Advanced healing with mitochondrial metabolic therapy,” the author presents how to follow his program.
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Part I, “Rescuing your metabolism,” details what mitochondria are and how they are affected by free radicals, dietary fats, iron, protein, and insulin. Mercola calls it the Mitochondrial Metabolic Therapy (MMT) program. The book describes a way of eating to shift your metabolism from burning glucose as your primary fuel to burning fat. Fat for fuel: A revolutionary diet to combat cancer, boost brain power, and increase your energy. New York: Hay House, Inc. It makes sense then that many health practitioners are looking at ways to strengthen and improve immune function.īy now, you’re probably aware that one of the lethal effects of COVID-19 is the virus’ ability to trigger a cytokine storm.Mercola, J., MD. Supplements and strategies that have been identified as capable of modulating immune responses and suppressing cytokine storm include but are not limited to: The good news is there are several strategies that appear very helpful in this respect. Buy New $32.49 ($0.36 / Count) (as of 04:49 UTC - Details)ĭHA and EPA May Ameliorate Cytokine StormĪccording to the opinion paper “The Potential Beneficial Effect of EPA and DHA Supplementation Managing Cytokine Storm in Coronavirus Disease,” published June 19, 2020, in the journal Frontiers in Physiology, EPA and DHA are known to affect biological pathways that “may have direct influence in the outcome of COVID-19”: 1 To this list, we can also add the omega-3 fats docosahexaenoic acid (DHA) and eicosapentaenoic acid (EPA), long-chained omega-3 fats found in cold-water fatty fish like wild-caught Alaskan salmon, sardines, anchovies and krill, just to name a few. Recent articles suggest that specific nutrients such as vitamin B6, B12, C, D, E, and folate trace elements, including zinc, iron, selenium, magnesium, and copper may play a key role in the management of cytokine storm … “To date, the molecular events that precipitate a ‘cytokine storm’ or the applicable therapeutic strategies to prevent and manage this process is not elucidated because of the complex nature of this problem. LC-PUFAs (long chain polyunsaturated fatty acids) such as EPA … and DHA … are noteworthy because of their direct influence in the immunological response to viral infections. Evidence suggests that n-3 LC-PUFAs can modulate the immune response and function in many ways.Īmong these complex immunomodulatory effects, interleukin-6 (IL-6) and interleukin-1ß (IL-1β) - because of the suspected central regulatory role in the ‘cytokine storm’ - should be highlighted. These cytokines can be affected by dietary EPA and DHA intake (Figure 1). In addition, poly(ADP-ribose) polymerase enzymes that have anti-inflammatory properties, translatable to human COVID-19 infection were shown to improve tissue levels of DHA and EPA, as well as the downstream anti-inflammatory metabolites of EPA and DHA further underscoring the applicability of DHA and EPA in COVID-19.”įigure 1: Main pathways for the metabolism of DHA and EPA yielding anti-inflammatory metabolites.
While not mentioned in this Frontiers in Physiology paper, animal-based omega-3 fats, especially DHA, have also been shown to prevent thrombosis (a blood clot within a blood vessel) by decreasing platelet aggregation. Protects against secondary bacterial infections.As discussed in “ COVID-19 Critical Care,” hypercoagulation is another complication of severe COVID-19 infection that can have lethal consequences. Unfortunately, the authors recommend using “algae- or plant-based sources of EPA and DHA” rather than marine-based sources. While microalgae 2 do contain DHA and EPA and are a viable source for strict vegetarians, as previously discussed in “ The Critical Differences Between Omega-3 Fats From Plants and Marine Animals,” most plant-based omega-3s actually do not contain any of the long-chain omega-3 fats, DHA and EPA.Īs mentioned, ideal sources of DHA and EPA are marine-based and include cold-water fatty fish like wild-caught Alaskan salmon, sardines and anchovies.
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